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1.
Chinese Journal of Hepatobiliary Surgery ; (12): 567-572, 2023.
Article in Chinese | WPRIM | ID: wpr-993375

ABSTRACT

Objective:To study the effect of diabetes mellitus (DM) on sepsis in patients with pyogenic liver abscess (PLA).Methods:The clinical data of 116 patients with PLA treated in the Affiliated Hospital of Jiangnan University from January 2021 to May 2022 were retrospectively analyzed, including 64 males and 52 females, aged (62.3±12.6) years old. Patients were divided into DM group ( n=56) and non-DM group ( n=60), which were also divided into the sepsis group ( n=29) and the non-sepsis group ( n=87). The clinical features were compared among the groups, the risk factors of PLA complicated with sepsis were analyzed by multivariate logistic regression. Mediation model was used to analyze how DM affects the development of sepsis. Results:Compared with the non-DM group, patients in DM group had higher incidences of hypertension and acute physiology and chronic health evaluation II, a higher proportion of blood neutrophil count, a higher serum levels of triglyceride, urea nitrogen, fasting blood glucose and glycated hemoglobin at admission. The DM group also higher incidences of hypoproteinemia, pleural effusion, and sepsis, with longer hospital stay and higher hospitalization cost (all P<0.05). The levels of hemoglobin, albumin and hematocrit were lower in DM group (all P<0.05). Multivariate logistic regression analysis showed that comorbidity of DM ( OR=3.431, 95% CI: 1.245-9.455) and abscess with a larger diameter ( OR=1.664, 95% CI: 1.258-2.220) were associated with a higher risk of developing sepsis (all P<0.05). Mediation model showed that neutrophil count and triglyceride were the mediating variables of sepsis in patients with PLA. Conclusion:Comorbidity of diabetes is an independent risk factor of developing sepsis in patients with pyogenic liver abscess. Diabetes may induce sepsis by affecting the neutrophils and triglyceride.

2.
Sichuan Mental Health ; (6): 340-346, 2023.
Article in Chinese | WPRIM | ID: wpr-987344

ABSTRACT

BackgroundChronic superficial gastritis (CSG) is a common clinical disease in children. The emotional behavior of CSG children is susceptible due to them suffering from such disease at young age. ObjectiveTo explore the impact of coping strategies on emotional behavior and the effect of family function in children with CSG, and to provide references for clinical intervention in CSG children with emotional behavior problems. MethodsA total of 177 children with CSG admitted to Anhui Children's Hospital from June 2019 to January 2023 were selected as the research subjects. Investigation on family function, emotional and behavioral problems and coping strategies of children was conducted by employing the Family APGAR index (APGAR), the Strengths and Difficulties Questionnaire (SDQ) and Coping Strategies Questionnaire (CSQ). The structural equation model was used to test the mediating effect of family function between coping strategies and emotional behaviors. ResultsThe APGAR score was negatively correlated with both SDQ score and negative coping strategies score (r=-0.507, -0.551, P<0.01), but was positively correlated with positive coping strategy score (r=0.579, P<0.01). The positive coping strategy score was negatively correlated with SDQ score (r=-0.539, P<0.01), while the negative coping strategy score was positively correlated with SDQ score (r=0.543, P<0.01). The result showed that family function played a partial mediating role between positive coping strategies and emotional behavior [indirect effect was -0.133 (95% CI: -0.256~-0.079, P<0.01), accounting for 29.40% of the total effect]. The same mediating effect happened between negative coping strategies and emotional behavior [indirect effect was 0.093 (95% CI: 0.198~0.045, P<0.01), accounting for 28.50% of the total effect]. ConclusionCoping strategies of CSG children can affect emotional behavior directly and indirectly with family function playing a partial intermediary effect.

3.
Journal of Peking University(Health Sciences) ; (6): 450-455, 2023.
Article in Chinese | WPRIM | ID: wpr-986875

ABSTRACT

OBJECTIVE@#To investigate the mechanism of self-efficacy between self-management ability and self-management behavior and its differences among patients with different disease courses through mediation tests.@*METHODS@#In the study, 489 patients with type 2 diabetes who attended the endocrinology departments of four hospitals in Shanxi Province and Inner Mongolia Autonomous Region from July to September 2022 were enrolled as the study population. They were investigated by General Information Questionnaire, Diabetes Self-Management Scale, Chinese version of Diabetes Empowerment Simplified Scale, and Diabetes Self-Efficacy Scale. Mediation analyses were performed using the linear regression model, Sobel test, and Bootstrap test in the software Stata version 15.0 and divided the patients into different disease course groups for subgroup analysis according to whether the disease course was > 5 years.@*RESULTS@#In this study, the score of self-management behavior in the patients with type 2 diabetes was 6.16±1.41, the score of self-management ability was 3.99±0.74, and the score of self-efficacy was 7.05±1.90. The results of the study showed that self-efficacy was positively correlated with self-management ability (r=0.33) as well as self-management behavior (r=0.47) in the patients with type 2 diabetes (P < 0.01). The mediating effect of self-efficacy accounted for 38.28% of the total effect of self-management ability on self-management behaviors and was higher in the behaviors of blood glucose monitoring (43.45%) and diet control (52.63%). The mediating effect of self-efficacy accounted for approximately 40.99% of the total effect for the patients with disease course ≤ 5 years, while for the patients with disease course > 5 years, the mediating effect accounted for 39.20% of the total effect.@*CONCLUSION@#Self-efficacy enhanced the effect of self-management ability on the behavior of the patients with type 2 diabetes, and this positive effect was more significant for the patients with shorter disease course. Targeted health education should be carried out to enhance patients' self-efficacy and self-management ability according to their disease characteristics, to stimulate their inner action, to promote the development of their self-management behaviors, and to form a more stable and long-term mechanism for disease management.


Subject(s)
Humans , Diabetes Mellitus, Type 2/therapy , Self Efficacy , Self-Management , Blood Glucose Self-Monitoring , Blood Glucose , Self Care
4.
Journal of Central South University(Medical Sciences) ; (12): 557-564, 2023.
Article in English | WPRIM | ID: wpr-982322

ABSTRACT

OBJECTIVES@#Pregnancy stress is the psychological confusion or threat caused by various stress events and adverse factors during pregnancy. Pregnant women exposed to many stressors, they will be easy to produce bad mood and prenatal depression if they cannot adapt to their own changes. Prenatal depression is one of the major global public health problems, with a higher incidence in developing countries and a negative impact on the health of pregnant women and fetus. Resilience refers to pregnant women using their own positive psychological capital, can self-emotional adjustment and improve their ability to adapt to the response state. A better level of resilience can enable pregnant women to face various negative and adaptive problems positively. This study aims to investigate the relationship between pregnancy stress, resilience and prenatal depression through a mental health survey of pregnant women.@*METHODS@#A total of 750 pregnant women in a Grade A tertiary hospital in Urumqi were investigated by self-designed demographic questionnaire, Pregnancy Pressure Scale (PPS) and Patient Health Questionnaire-9 (PHQ-9), Connor-Davidson Resilience Scale (CD-RISC), and the levels of stress during pregnancy, prenatal depression and resilience were analyzed. Pearson correlation analysis was used to explore the correlation between the three. Bootstrap mediation effect test was used to test the mediation effect relationship among the three. If the mediation effect was confirmed, AMOS software was used to establish the mediation effect structural equation model to analyze the mediation effect among the three.@*RESULTS@#Among 750 respondents, 709 (94.53%) had mild or above pregnancy pressure, 459 (61.20%) had mild or above depressive symptoms and 241 (32.13%) had a good or above level of resilience. Pearson correlation analysis showed that prenatal depression was significantly positively correlated with pregnancy stress (P<0.01), prenatal depression and pregnancy stress were significantly negatively correlated with resilience (all P<0.01). Mediation effect test analysis showed that all the pathways were statistically significant (P<0.01). Mediation effect of resilience between pregnancy stress and prenatal depression was significantly found (95% CI 0.022-0.068, P<0.001). Pregnancy pressure negatively affected resilience (β=-0.38, P<0.01), and resilience negatively affected prenatal depression (β=-0.10, P<0.01). The mediation effect of resilience was 6.5%.@*CONCLUSIONS@#Pregnant women's pregnancy pressure, resilience and prenatal depression are significantly correlated, and the mediation variable resilience plays a partial mediating role in the impact of pregnancy pressure on prenatal depression. Pregnant women can reduce the incidence of prenatal depression and promote their physical and mental health by exercising their resilience.


Subject(s)
Pregnancy , Humans , Female , Depression/epidemiology , Pregnant Women , Exercise , Fetus , Mental Health
5.
Shanghai Journal of Preventive Medicine ; (12): 1100-1105, 2023.
Article in Chinese | WPRIM | ID: wpr-1003817

ABSTRACT

ObjectiveTo study the relationship between occupational stress/sleep quality and job satisfaction of internet enterprise programmers, to explore the mediating effect of sleep quality between occupational stress and job satisfaction, and to provide a theoretical basis for taking effective measures to improve job satisfaction. MethodsA total of 271 programmers from an Internet company in Shanghai were investigated by job content questionnaire, Pittsburgh Sleep Index Scale and the third part of the McLean occupational stress questionnaire. The results were statistically analyzed ResultsThe positive rate of occupational stress of programmers in this enterprise was 66.7%, 34.3% of them had average sleep quality, 28.0% had poor sleep quality, and the score of job satisfaction was 47.70±6.78. Correlation analysis showed that the higher the occupational stress, the worse the sleep quality and the lower the job satisfaction. Effects of occupational stress and sleep quality on job satisfaction were both statistically significant. The total effect of occupational stress on job satisfaction was -0.35, and the mediating effect of sleep quality between occupational stress and job satisfaction was -0.04, accounting for 12.0% of the total effect. ConclusionSleep quality of internet enterprise programmers plays a partial mediating role between occupational stress and job satisfaction, and a series of measures such as improving sleep can be taken to improve programmer’s job satisfaction.

6.
Chinese Journal of Clinical Nutrition ; (6): 19-26, 2022.
Article in Chinese | WPRIM | ID: wpr-931738

ABSTRACT

Objective:To explore the effects of myosteatosis and blood glucose (BG) on postoperative complications in non-diabetic gastric cancer patients receiving supplemental parenteral nutrition (SPN) after gastrectomy.Methods:Patients who underwent radical gastrectomy between March 2017 and June 2021 in the Department of Surgical Oncology, the First Hospital of Lanzhou University were included in this study. Various preoperative inflammatory and nutritional indicators, including skeletal muscle metrics at the third lumbar level on CT, were collected retrospectively. Postoperative BG within 3 days and complications within 30 days were monitored. Patients were divided into two groups according to the presence or absence of myosteatosis (assessed via skeletal muscle density [SMD]) and the differences in postoperative BG and complication incidence were compared. Mediation model was used to analyze the mediating effect of BG in the association between SMD and postoperative complications.Results:A total of 357 patients were included in the study. Compared with the 299(83.8%) patients without myosteatosis , the incidence of hyperglycemia, mean BG, maximal BG, and BG fluctuation while on SPN in the 58(16.2%) patients with myosteatosis were higher, and the comprehensive complication index (CCI) and the incidence of complication were higher ( P<0.05). More importantly, BG showed the mediation effect of -0.0892 in the effect of SMD on CCI ( P<0.05), with the effect size of 19.3%. Conclusion:Myosteatosis and postoperative hyperglycemia are associated with higher incidence of complications, and BG plays an intermediary role in the association between myosteatosis and CCI.

7.
Journal of Environmental and Occupational Medicine ; (12): 343-347, 2022.
Article in Chinese | WPRIM | ID: wpr-960414

ABSTRACT

Air pollution has become one of the most important public health problems worldwide. Exposure to air pollution during pregnancy is one of the important risk factors for adverse birth outcomes such as preterm birth, low birth weight, and birth defects. Air pollution control has a long way to go. Therefore, it is extremely urgent to analyze and identify relevant protective factors. Some studies have shown that green space may be a protective factor for the adverse birth outcomes related to air pollution. This kind of research mainly utilizes satellite monitoring data, quantifies the green space coverage level in a certain range of buffer zone centered on the pregnant women's home addresses, and analyzes its mediation effect on the adverse pregnancy outcomes related to air pollution. In this paper we reviewed the use of green space data, the estimated effect of green space mediating the relationship between air pollution and adverse birth outcomes, and its possible mechanisms, aiming to clarify the impact of green space on adverse birth outcomes related to air pollution and provide a scientific basis for public health intervention strategies.

8.
Journal of Environmental and Occupational Medicine ; (12): 281-288, 2022.
Article in Chinese | WPRIM | ID: wpr-960405

ABSTRACT

Background Preterm birth-related complications are the leading cause of death in newborns and children under the age of 5 years. Maternal heat exposure has been associated with both sleep status during pregnancy and the increased risk of preterm birth. However, whether sleep status could mediate the association between heat exposure and preterm birth remains unclear. Objective To evaluate the association between maternal heat exposure in early pregnancy and preterm birth, and to further explore potential mediation effect of sleep status on the association between heat exposure and preterm birth. Methods A birth cohort was established in Guangzhou Panyu Maternal Child Health Hospital (Guangzhou Panyu District He Xian Memorial Hospital) from 2017 until now. Pregnant women (with gestational age between 8 and 13 weeks) were included in this study when they presented to the hospital for their first prenatal care visit and signed an informed consent. Then they were followed up until delivery. A total of 3 268 pregnant women were included for the final analysis. Questionnaires were distributed to collect the demographic characteristics, lifestyles, and sleep status of pregnant women. Daily meteorological data during the study period were collected from meteorological monitoring stations in Guangzhou and the average ambient mean temperature of four weeks before the survey was calculated and assigned for each pregnancy. The 75th, 80th, 85th, 90th, and 95th percentiles (P75, P80, P85, P90, and P95) of the average ambient temperature of all pregnant women were used as the thresholds to define heat exposure. Logistic regression was used to evaluate the effects of heat exposure in different definitions on preterm birth and sleep status (sleep duration, night sleep timing, and wake up timing). The mediation effects of sleep status on the relationship between heat exposure and preterm birth were also analyzed. Results Among all the included participants, 165 newborns were preterm births with an incidence rate of 5.0%. Heat exposures with thresholds of P90 and P95 increased the risk of preterm birth, with ORs (95%CIs) of 1.66 (1.04-2.57) and 1.90 (1.03-3.33), respectively (P<0.05). Heat exposures with thresholds of P75, P80, P85, P90, and P95 decreased the sleep duration (<9 h vs. ≥9 h, control group: ≥9 h), and the ORs (95%CIs) were 1.51 (1.25-1.83), 1.44 (1.17-1.77), 1.35 (1.08-1.70), 1.43 (1.09-1.87), and 1.45 (1.00-2.13), respectively. Heat exposures with P75 and P80 thresholds resulted in earlier wake up timing (<8: 00 vs. ≥8: 00, control group: <8: 00), with ORs (95%CIs) of 0.77 (0.63-0.93) and 0.76(0.61-0.93), respectively. No significant association was observed between heat exposure and night sleep timing. The mediation analyses showed that under heat exposure with P90 threshold, a statistically significant mediation effect was observed for sleep duration, and the proportion mediated was 6.07% (95%CI: 0.17%-25.00%) (P<0.05). No significant mediation effect was observed for night sleep timing and wake up timing. Conclusion An elevated risk of preterm birth after heat exposure in early pregnancy may be partly mediated through reducing sleep duration.

9.
Sichuan Mental Health ; (6): 418-423, 2022.
Article in Chinese | WPRIM | ID: wpr-987373

ABSTRACT

The purpose of this paper was to introduce how to set the options of variable levels and multimodal covariates, and to demonstrate the causal mediation effect analysis method with odds ratio (OR) and excess relative risk (ERR) as evaluation indicators through examples. For treatment variables, mediator variables and covariates, the variable-level options of them could be set through the evaluate statement. For categorical variables and their interaction terms, they could be treated as multimodal covariates, and the variable levels could also be set for them by using the evaluate statement. Through an example, this paper used SAS to realize the causal mediation effect analysis and the decomposition of effect components with OR and ERR as the evaluation indicators.

10.
Sichuan Mental Health ; (6): 412-417, 2022.
Article in Chinese | WPRIM | ID: wpr-987372

ABSTRACT

The purpose of this paper was to introduce the setting method of the three types of variable levels in the causal mediation effect analysis and the implementing calculation method under the condition of stratification by using SAS. The setting of the three types of variable levels referred to the setting of the levels of treatment variable, the mediator variable and the covariate. Besides, a specific level combination could also be set for two variables. Through an example, with the help of the enveluate statement in proc causualmed procedure, this paper used an example to conduct the causal mediation effect based on different variable stratification, and gave the output results and explanations.

11.
Sichuan Mental Health ; (6): 407-411, 2022.
Article in Chinese | WPRIM | ID: wpr-987371

ABSTRACT

The purpose of this paper was to introduce five key techniques and the multi-directional decomposition methods of effect components in the analysis of causal mediation effects. The contents of the five key technologies were as follows: ① identification of causal mediation effect; ② regression method of causal mediation effect analysis; ③ maximum likelihood estimation; ④ estimation of total effect and various component effects; ⑤ estimation by bootstrap method. The multi-directional decomposition methods included 3 bidirectional decompositions, 2 three-directional decompositions and 1 four-directional decomposition. Through an example, a causal mediation effect analysis model including covariates and interaction terms was constructed with the help of SAS, bidirectional decomposition, three-directional decomposition and four-directional decomposition were carried out for the total effect in the causal mediation effect analysis, and the output results were explained.

12.
Sichuan Mental Health ; (6): 402-406, 2022.
Article in Chinese | WPRIM | ID: wpr-987370

ABSTRACT

The purpose of this paper was to introduce the theoretical basis of the causal mediation effect analysis and the specific method to realize an example by the causal mediation effect analysis with SAS. The theoretical basis of the causal mediation effect analysis included the following two aspects, the basic concept and defining the counterfactual framework of the causal mediation effect. The example was about whether the encouraging environment provided by parents would affect the cognitive development of children. The traditional multiple linear regression analysis, the causal mediation effect analysis without considering covariates and with considering covariates were used, respectively. By comparing the results obtained by the three analysis methods, the following conclusions were drawn: ① when there were the mediation variables in the data, it was not suitable to use traditional multiple linear regression analysis to replace the causal mediation effect analysis; ② when there were covariates in the data, it was not suitable to conduct causal mediation analysis under the condition of ignoring covariates.

13.
Organ Transplantation ; (6): 378-2022.
Article in Chinese | WPRIM | ID: wpr-923585

ABSTRACT

Objective To investigate the influence of perceptions and emotional attitudes on the public's willingness to organ donation and its path of promotion. Methods The mediation effect and structural equation models were established through the convenience sampling method and with ABC attitude model as the theoretical basis to analyze the influence of perceptions and emotional attitudes on the public's willingness to organ donation and the path of promotion. Results Among 4 565 investigated subjects, 621 subjects expressly stated that they were not willing to donate their organs after the death, 701 subjects were willing to donate their organs after the death, but only 259 investigated subjects signed the informed content card of organ donation. The differences in the subjects' willingness to donate their organs were statistically significant in terms of different genders, ages, religious beliefs, places of residence and educational degrees (all P < 0.05). The overall Cronbach's α coefficient of the questionnaire was 0.781, KMO=0.842, with good reliability and validity. In the structural equation model, the path coefficient of perceptions on the willingness to donation was 0.39, while that of attitudes on the willingness was 0.25. As such, perceptions and emotional attitudes had positive impacts on the willingness to donate the organs. The results of the mediation effect model indicated that attitudes played significant mediation effects in the causality relationship of perceptions on the willingness to donate organs, and the mediation effect value was 0.035(P < 0.01). The awareness degree of organ donation was the largest determinant to the perception factor, and the path coefficient on the willingness to donation was 0.20. The sense of social honor was the largest determinant to the attitude factor, and the path coefficient was 0.16. Conclusions Both perceptions and emotional attitudes positively impact the willingness to donate organs. The awareness degree of organ donation is the largest determinant to the perception factor, while the sense of social honor is the largest determinant to the attitude factor. To improve the public's perception level towards the organ donation and increase the public's sense of social honor towards organ donation contributes to the improvement of the public's willingness to donate organs.

14.
Chinese Journal of Disease Control & Prevention ; (12): 57-61,72, 2020.
Article in Chinese | WPRIM | ID: wpr-793318

ABSTRACT

Objective Analyze the correlation of depression between the childhood abuse behavior and adulthood cyberbullying behavior, so as to discuss and provide evidences for preventing the cyberbullying behavior of college students. Methods A total of 4 040 college students were surveyed after multistage stratified cluster random sampling from 6 universities in Shanxi Province of China by using childhood trauma questionnaire, self-rating depression scale and cyberbullying scale. Results In the three dimensions of cyberbullying, cyber-verbal bullying behavior, identity concealing behavior and cyber-forgery fraud behavior, male students and only child students scored higher than that of female students and non-only child students (all P<0.001). There was a positive correlation between childhood abuse, adult depression and cyberbullying (all P<0.001). The mediation effect results showed that depression symptoms of college students were mediating between childhood abuse experience and cyberbullying behavior (the mediation effect result was 0.090, P<0.001), the mediation effect contributed 12.16% to the total effect, the mediation model fitting index were 2/df=39.96,RMSEA=0.101,CFI=0.948,TLI=0.924,SRMR=0.043. Conclusions Childhood abuse experience and adulthood depression are closely related to the implementation of cyberbullying behavior in college, and depression plays part of mediating role in predicting the implementation of cyberbullying behavior in college students who has childhood abuse experience.

15.
Acta investigación psicol. (en línea) ; 10(2): 43-55, abr. 2020. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1152712

ABSTRACT

Resumen La Agencia humana ha sido estudiada desde varias disciplinas de las ciencias sociales y aunque tienen similitudes en su conceptualización y características, existe un aislamiento en su estudio y ausencia de comunicación entre disciplinas. Se buscó probar el efecto de mediación de los tres modos de Agencia propuestos por Bandura en el contexto del aprendizaje en educación superior. Los análisis factoriales confirmatorios por modelamiento de ecuaciones estructurales de los resultados de la aplicación a estudiantes universitarios, del Inventario de Agencia en Situaciones Escolares (IASE), elaborado exprofeso para este estudio, permitió probar un efecto de mediación entre la agencia personal y la agencia colectiva a través de la agencia mediada. La relación tríadica de la agencia propuesta por la teoría, centrada en situaciones escolares, es un aporte a la etnopsicometría que permite asumir el papel de múltiples factores en el proceso de adquisición de aprendizajes complejos.


Abstract The Human Agency has been studied from various Social Science disciplines and although they exhibit similarities in their conceptualization and characteristics, a lack of communication between disciplines is detected. We sought to test the mediation effect of the three modes of Agency proposed by Bandura in the context of learning in higher education. A confirmatory factor analysis of the Inventory of Agency in School Situations, elaborated for this study, allowed to prove a mediation effect between the personal agency and the collective agency through the mediated agency. The triadic relationship of agency proposed by the theory, centered on school situations, is a contribution to ethnopsychometry that allows us to assume the role of multiple factors in the process of acquiring complex learning.

16.
Chinese Journal of Disease Control & Prevention ; (12): 1057-1061,1106, 2019.
Article in Chinese | WPRIM | ID: wpr-779465

ABSTRACT

Objective To analyze the mechanism of the influencing factors of myopia for junior high school students in China. Methods Based on the follow-up to 7 119 students in the 3 waves of questionnaire survey of the Chinese Education Panel Survey in junior high school stage, and the variables on students’ myopia status, myopia influencing factors, and two kinds of risk behaviors of myopia including near visual activities and outdoor activities, the mediation effects of the myopia risk behaviors were tested by Logistic regression model. Results The myopia prevalence of 9th graders before junior high school graduation was 66.36%. Time on writing homework significantly increased the risk of myopia,the odds ratio (OR) was 1.17,the 95% confidence interval (CI) was 1.13-1.21, and the time on outdoor sports significantly decreased the risk of myopia (OR=0.80,95% CI:0.75-0.86). Before and after including the risk behaviors into the model, the myopia risk OR(95% CI) of female centralized from 1.84(1.66-2.04) to 1.69(1.51-1.88), the myopia risk OR(95% CI) of urban students’centralized from 1.19(1.03-1.37) to 1.16(1.00-1.34), the myopia risk OR(95% CI) of only children’centralized from 1.20(1.06-1.36) to 1.18(1.04-1.33). With reference to not myopic for both parents, the myopia risk OR(95% CI) of students having one myopic parent centralized from 2.47(2.12-2.88) to 2.44(2.09-2.85), the myopia risk OR(95% CI) of students having parent without myopic centralized from 4.25(3.09-5.86) to 4.13(3.00-5.69). Conclusions Gender, urban and rural, only child, and myopic parents are influencing factors of myopia. These factors have effects on myopia via two kinds of risk behaviors including outdoor activities and near visual activities.

17.
Chinese Journal of Epidemiology ; (12): 590-595, 2019.
Article in Chinese | WPRIM | ID: wpr-805209

ABSTRACT

Objective@#To evaluate the possible mediation effect of DNA methylation in the associations between birth weight and adulthood obesity in women in China.@*Methods@#A cross-sectional survey was conducted in 1 602 women with genetic relationship in urban area of Shanghai during March-December 2016. Information about their birth weight, birth length, current lifestyle and disease history were collected and body measurement was conducted at the interview. DNA methylation at specific sites of GNASAS, IGF2, IGF2-R, IL10 and LEP were measured using bisulphite pyrosequencing. Generalized estimating equations models with restricted cubic spline functions were used to estimate the associations of birth weight with BMI, waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-hip ratio (WHtR) in adulthood, and their associations with DNA methylation were evaluated using multilevel linear models. Multilevel structural equation models were used to evaluate the mediation effect of DNA methylation.@*Results@#A significant non-linear association was observed between birth weight and WC as well as WHtR (P<0.05). Lower birth weight was associated with higher level of methylation at IGF2-DMR (CpG1, 2), IGF2-R (CpG8, 10, 13, 16 and 17), with β coefficients and 95%CI being -4.35 (-7.30- -1.39), -4.50 (-7.59- -1.41), -2.33 (-4.60- -0.05), -1.78 (-3.88- -0.33), -2.58 (-4.82- -0.34), -2.03 (-4.00- -0.06) and -1.87 (-3.73- -0.01), respectively, but related with a lower level of methylation at LEP CpG16 (β=4.19, 95%CI: 0.37- 8.00). Lower level of methylation at IGF2-DMR (CpG7), IGF2-R (CpG3, 5, 8, 9, 10, 14, 17, 19) and LEP (CpG3, 8, 10) was associated with larger WC, with β coefficients ranging from -0.016 to -0.040 (all P<0.05). Methylation at IGF2-R CpG8 was observed to mediate the association of birth weight and WC, and could explain 3.3% of the association.@*Conclusion@#Our results suggested that DNA methylation might mediate the effect of nutrition in uteri on adulthood central obesity in women in China.

18.
Journal of Nutrition and Health ; : 567-579, 2018.
Article in Korean | WPRIM | ID: wpr-718555

ABSTRACT

PURPOSE: This study examined the mediation effects of dietary habits, nutrient intake, daily life in the relationship between the working hours of Korean shift workers and metabolic syndrome. METHODS: Data were collected from the sixth (2013–2015) Korea National Health and Nutrition Examination Survey (KNHANES). The stochastic regression imputation was used to fill missing data. Statistical analysis was performed in Korean shift workers with metabolic syndrome using the SPSS 24 program for Windows and a structural equation model (SEM) using an analysis of moment structure (AMOS) 21.0 package. RESULTS: The model fitted the data well in terms of the goodness of fit index (GFI) = 0.939, root mean square error of approximation (RMSEA) = 0.025, normed fit index (NFI) = 0.917, Tucker-Lewis index (TLI) = 0.984, comparative fit index (CFI) = 0.987, and adjusted goodness of fit index (AGFI) = 0.915. Specific mediation effect of dietary habits (p = 0.023) was statistically significant in the impact of the working hours of shift workers on nutrient intake, and specific mediation effect of daily life (p = 0.019) was statistically significant in the impact of the working hours of shift workers on metabolic syndrome. On the other hand, the dietary habits, nutrient intake and daily life had no significant multiple mediator effects on the working hours of shift workers with metabolic syndrome. CONCLUSION: The appropriate model suggests that working hours have direct effect on the daily life, which has the mediation effect on the risk of metabolic syndrome in shift workers.


Subject(s)
Feeding Behavior , Hand , Korea , Negotiating , Nutrition Surveys
19.
Korean Journal of Clinical Pharmacy ; : 238-242, 2018.
Article in Korean | WPRIM | ID: wpr-717142

ABSTRACT

BACKGROUND: The appropriate use of drugs is very important for a healthy life, as appropriate medication must be taken correctly for successful treatment of a disease. The purpose of this study was to investigate the self-efficacy between health status and drug abuse behavior. METHODS: The subjects of this study were selected from 15 workshops located in Seoul, Incheon, Daejeon, and Chungnam, and, convenience sampling was conducted for each employee between September, 2017 and October 2017. A total of 204 questionnaires were analyzed. The questions evaluated health status, self-efficacy, drug abuse behavior, and general characteristics. RESULTS: First, there was no difference in health status according to the general characteristics of the subjects. The self-efficacy varied according to gender, educational background, and monthly income, but not by marital status and residence area. In addition, drug abuse behaviors differed according to gender, residence area, and monthly income, but not by marital status and education level. Second, drug abuse behavior negatively correlated with health status and self-efficacy. Third, regression analysis showed that the self-efficacy between the health status and drug abuse behavior had a partially mediating effect. CONCLUSION: In patients with poor health status, it is necessary to increase their self-efficacy to reduce reduce drug abuse. Therefore, regular education programs targeting efficacy and drug knowledge are required in the community.


Subject(s)
Humans , Education , Marital Status , Negotiating , Seoul , Substance-Related Disorders
20.
Academic Journal of Second Military Medical University ; (12): 92-96, 2018.
Article in Chinese | WPRIM | ID: wpr-838235

ABSTRACT

Objective To investigate the relationship between anxiety sensitivity (AS), resilience and mental health of soldiers. Methods A total of 260 soldiers were selected from an army troop, and were surveyed by anxiety sensitivity index Ⅲ (ASI-3), Conner-Davidson resilience scale (CD-RISC) and self-reporting inventory (SCL-90). The relationships of these variables were analyzed by structure equation modeling analysis. Results Totally 240 (92.3%) valid questionnaires were collected. There were no significant differences in AS or mental health between soldiers with different demographic factors including service length, single-child or not, job division, educational level, or residence before entering army (P>0.05). The total score of SCL-90 and each factor scores of soldiers with high-AS were significantly higher than those with low-AS (P<0.01). The correlation analysis results showed that the total score of SCL-90 was positively correlated with the total score and each factor score of ASI-3 (rASI =0.487, rsomatic=0.435, rsocial=0.455, rcognitive=0.445; P<0.001), and was negatively correlated with each factor score of CD-RISC (rtenacity =0.315, rstrength =0.321, roptimism =0.227; P<0.001). Structural equation modeling analysis and Sobel test showed that AS indirectly affected the mental health of soldiers through the mediating effect of resilience (χ2/df=20.222/12=1.685 2, P=0.063, goodness of fit index [GFI]=0.977, adjusted goodness of fit index [AGFI]=0.946, normed fit index [NFI]=0.977, relative fit index [RFI]=0.960, incremental fit index [IFI]=0.991, Tucker-Lewis index [TLI]=0.983, comparative fit index [CFI]=0.990, and root mean square error approximation [RMSEA]=0.054). Conclusion RS has partial mediating effect on the relationship between AS and mental health of soldiers. More attention should be paid on the mental health of soldiers with high AS, so as to improve their RS and mental health.

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